19 F NMR Spectroscopic Analysis of the Binding Modes in Triple-Helical Peptide Nucleic Acid (PNA)/MicroRNA Complexes.

@article{Thtinen201719FN,
  title={19 F NMR Spectroscopic Analysis of the Binding Modes in Triple-Helical Peptide Nucleic Acid (PNA)/MicroRNA Complexes.},
  author={Ville T{\"a}htinen and Lotta Granqvist and Merita Murtola and R. Str{\"o}mberg and Pasi Virta},
  journal={Chemistry},
  year={2017},
  volume={23 29},
  pages={7113-7124}
}
Triplex-forming peptide nucleic acids (TFPNAs) were targeted to double-helical regions of 19 F-labeled RNA hairpin models (a UA-rich duplex with a hexaethylene glycol (heg) loop and a microRNA model, miR-215). In addition to conventional UV- and circular dichroism (CD)-based detection, binding was monitored by 19 F NMR spectroscopy. Detailed information on… CONTINUE READING