19(S)-hydroxyeicosatetraenoic acid is a potent stimulator of renal Na+-K+-ATPase.

  title={19(S)-hydroxyeicosatetraenoic acid is a potent stimulator of renal Na+-K+-ATPase.},
  author={Bruno A. Escalante and John R Falck and P Yadagiri and Linda Sun and Michal Laniado-Schwartzman},
  journal={Biochemical and biophysical research communications},
  volume={152 3},
Omega- and omega-1 hydroxylations are the major pathways by which arachidonic acid is metabolized in cortical and outer medullary microsomes of rat and rabbit kidneys. It is a cytochrome P450-dependent oxidation leading to the formation of 20-hydroxy- and 19-hydroxyeicosatetraenoic acids. In this study, we compared the effects of the synthetically prepared omega- and omega-1 metabolites of arachidonic acid on the activity of the renal Na+-K+-ATPase partially purified from rat renal cortical… CONTINUE READING