18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design.

@article{Blundell198818thSH,
  title={18th Sir Hans Krebs lecture. Knowledge-based protein modelling and design.},
  author={Tom L. Blundell and Desmond P Carney and Shea Gardner and Fiona Hayes and B. J. Howlin and Tim Hubbard and John P. Overington and Dr A Singh and Bancinyane Lynn Sibanda and Maxine Sutcliffe},
  journal={European journal of biochemistry},
  year={1988},
  volume={172 3},
  pages={513-20}
}
A systematic technique for protein modelling that is applicable to the design of drugs, peptide vaccines and novel proteins is described. Our approach is knowledge-based, depending on the structures of homologous or analogous proteins and more generally on a relational data base of protein three-dimensional structures. The procedure simultaneously aligns the known tertiary structures, selects fragments from the structurally conserved regions on the basis of sequence homology, aligns these with… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Similar Papers

Loading similar papers…