18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis.

@article{Yamanouchi200718alphaglycyrrhetinicAI,
  title={18alpha-glycyrrhetinic acid induces phenotypic changes of skeletal muscle cells to enter adipogenesis.},
  author={Keitaro Yamanouchi and Erica Yada and Naomi Ishiguro and Masugi Nishihara},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  year={2007},
  volume={20 6},
  pages={781-90}
}
The importance of connexins is implicated in proliferation and differentiation of cells. In skeletal muscle cells, connexin43 (Cx43) has been identified as the major connexin, and gap-junctional communication mediated by connexins has been shown to be required for their myogenic differentiation. In addition, inhibition of connexin function has been shown to induce transdifferentiation of osteoblasts to an adipocytic phenotype. In the present study, we examined whether the inhibition of connexin… CONTINUE READING

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