18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

  title={18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.},
  author={Rebecca Y Klinger and Olga G. James and Salvador Borges-Neto and Tiffany L Bisanar and Yi-Ju Li and Wenjing Qi and Miles Berger and Niccol{\`o} Terrando and Mark F. Newman and P. Murali Doraiswamy and Joseph Palackal Mathew and John C. Morris and Greg Sorensen and Maria Chrisina Carrillo and Lew Kuller and Marc Raichle and Peter Davies and Howard M. Fillit and Franz Hefti and David Holtzman and M. Marcel Mesulam and Peter Snyder and Adam Schwartz and Sarah Walter and Archana B. Balasubramanian and Jennifer Mason and Iris Sim and Laurel A Beckett and Nick Fox and Paul Thompson and Norbert Schuff and Charles DeCarli and Prashanthi Vemuri and David Jones and Chet A. Mathis and Louis Nigel J Cairns and Lisa Taylor-Reinwald and Lean Thal and Leon J. Thal and Neil S. Buckholtz and Peter J. Snyder and William Z. Potter and Steven Paul and Richard Frank and Zaven S. Khachaturian and John K. Hsiao and Jeffrey A. Kaye and Joseph T. Quinn and Lisa C. Silbert and Betty Lind and Raina Carter and Sara Dolen and Liberty Teodoro and Bryan M. Spann and Judith L. Heidebrink and Joanne L. Lord and S. S. Mason and Colleen S. Albers and David Knopman and Karen Johnson and Rachelle Doody and Javier Villanueva-Meyer and Valory N. Pavlik and Victoria Shibley and Munir Chowdhury and Susan D. Rountree and Mimi Dang and Beau M. Ances and Maria B. Carroll and Mary L. Creech and Erin E Franklin and Mark A. Mintun and Stacy Schneider and Angela Oliver and Daniel Marson and David Geldmacher and Marissa Natelson Love and Randall G Griffith and David F. Clark and John C. Brockington and Erik D Roberson and Hillel T. Grossman and Effie M. Mitsis and Leyla deToledo-Morrell and Maria T Greig-Custo and Warren Barker and Marilyn S. Albert and Chiadi Onyike and Daniel D'Agostino and Stephanie A. Kielb and Martin J Sadowski and Mohammed O Sheikh and Anaztasia Ulysse and Mrunalini Gaikwad and Terence Z. Wong and Edward Coleman and Steven E Arnold and Jason H. T. Karlawish and David A. Wolk and C. M. Clark and Charles D Smith and Greg Jicha and Peter Hardy and Partha Sinha and Elizabeth Oates and Gary Conrad and Oscar L. Lopez and M. Oakley and Donna M. Simpson and Bonnie S. Goldstein and Kim Martin and Kelly M. Makino and M. Saleem Ismail and Connie Brand and Kyle B. Womack and Dana Mathews and Mary Quiceno and Allan I. Levey and James J Lah and Janet S. Cellar and Jeffrey M. Burns and Russell Howard Swerdlow and William M. Brooks and Liana G. Apostolova and Kathleen D Tingus and Ellen Woo and Daniel H. S. Silverman and P. H. Lu and George Bartzokis and Neill R. Graff-Radford and Francine C Parfitt and Kim Poki-Walker and Martin R. Farlow and Ann Marie Hake and Brandy R. Matthews and Jared R Brosch and Scott Herring and Christopher H. van Dyck and Richard E. Carson and Martha G Macavoy and Pradeep Varma and Howard M. Chertkow and Howard Bergman and Chris Hosein and Sandra Black and Bojana Stefanovic and Curtis Caldwell and Ging-Yuek and Robin Ging-Yuek Hsiung and Benita Mudge and Vesna Sossi and Howard H. Feldman and Michele Assaly and Stephen Pasternack and Irina Rachisky and Dick Trost and Charles Bernick and Donna Munic and Emily J. Rogalski and Kristine Lipowski and Sandra Weintraub and Borna Bonakdarpour and Diana R. Kerwin and Chuang-Kuo Wu and Nancy Johnson and Kathleen Johnson and Jerome A Yesavage and Barton Lane and Allyson Rosen and Jared Tinklenberg and Christine Belden and Neil W. Kowall and Ronald J. Killiany and Andrew E. Budson and Alexander Norbash and Patricia Lynn Johnson and Alexandria Lerner and Paula J Ogrocki and Curtis Tatsuoka and Parianne Fatica and Evan Fletcher and Pauline Maillard and John M. Olichney and Owen Carmichael and Smita Kittur and Michael Borrie and T -Y Lee and Dr Rob Bartha and Sterling C. Johnson and Sanjay Asthana and Cynthia M. Carlsson and Pierre N. Tariot and Anna M Burke and Ann Marie Milliken and Nadira Trncic and Adam Fleisher and Stephanie Reeder and Vernice Bates and Horacio A Capote and Michelle M Rainka and Douglas W Scharre and Maria Kataki and B. J. Kelley and Earl A. Zimmerman and Dzintra F Celmins and Alice E. Brown and Godfrey D. Pearlson and Karen Blank and Karen Anderson and L. A. Flashman and Marc A. Seltzer and Mary L. Hynes and Robert B. Santulli and Kaycee M Sink and Leslie Gordineer and Jeff D. Williamson and Pankaj Garg and F. J. Watkins and Brian R. Ott and Geoffrey Tremont and Lori A Daiello and Stephen P. Salloway and Paul J Malloy and Stephen Correia and Howard J. Rosen and Bruce LowekampNancy Miller and Kenneth M. Spicer and David F Bachman and Elizabeth Finger and Stephen Pasternak and Irina Rachinsky and John Rogers and Andrew Kertesz and Dick J. Drost and Nunzio Pomara and Raymundo T. Hernando and Antero Sarrael and Susan K. Schultz and Karen Ekstam Smith and Hristina Koleva and Ki Won Nam and Hyungsub Shim and Mi Lin and Amanda Smith and Balebail Ashok Raj and Kristin Fargher and Jordan Grafman and Robert C Green and Tom Montine and Michael Weiner and Ronald Petersen and Paul S. Aisen and Ronald G. Thomas and Devon Gessert and Tamie Miura Sather and Melissa Davis and Rosemary Morrison and Gus Jiminez and Thomas Neylan and Jacqueline Hayes and Shannon Finely and Danielle Harvey and M. Donohue and Clifford R. Jack and Matthew Bernstein and Bret Borowski and Jeff Gunter and Matt Senjem and Kejal Kantarci and Chad Ward and Robert A. Koeppe and Norm Foster and Eric M. Reiman and Kewei Chen and Nigel J. Cairns and Erin Householder and Leslie M. Shaw and John Q. Trojanowki and Virginia Lee and Magdalena Korecka and Michal J Figurski and Arthur W. Toga and Karen H Crawford and Scott Neu and Andrew J. Saykin and Tatiana Foroud and Steven G. Potkin and Li Shen and Kelley Faber and Sungeun Kim and Kwangsik Nho and Michael W Weiner and Karl Friedl and L. S. Schneider and Sonia Pawluczyk and Mauricio Becerra and James Brewer and Helen Vanderswag and Yaakov Stern and Lawrence S. Honig and Karen L. Bell and Debra A. Fleischman and Konstantinos Arfanakis and Raj C. Shah and Ranjan Duara and Daniel Varon and Maria T. Greig and Jeffrey R. Petrella and Anton P. Porsteinsson and Kimberly S Martin and Adrian Preda and Dana Nguyen and Jacobo E. Mintzer and Dino Massoglia and Olga Brawman-Mintzer and Carl H. Sadowsky and Walter Martinez and Teresa Villena and William J. Jagust and Susan Landau and David R. Perry and Raymond Scott Turner and Kelly Behan and Brigid A. Reynolds and Reisa A. Sperling and Keith A. Johnson and Gad A. Marshall and Marwan N. Sabbagh and Sandra A. Jacobson and Sherye A. Sirrel and Thomas O. Obisesan and Saba Wolday and Joanne S. Allard and J. Jay Fruehling and Sandra Harding and E. R. Peskind and Eric C. Petrie and Gail Li and Joy L. Taylor and A J Furst and Steven Chao and Norman Relkin and Gloria Chiang and L D Ravdin and Jorn A Karhausen and Miklos D Kertai and Mihai V Podgoreanu and Mark Stafford-Smith and Madhav Swaminathan and David Sjoquist Nick Warner and Bonita L Funk and Narai Balajonda and Rachele Brassard and Mary Cooter and Yanne Toulgoat-Dubois and Peter Waweru and Michael A. Babyak and James A. Blumenthal and Jeffrey N. Browndyke and Kathleen Welsh-Bohmer and Michael H. Sketch and Ellen R. Bennett and Carmelo Graffagnino and Daniel T Laskowitz and Warren J. Strittmatter and K. Collins and Greg R Smigla and I. Shearer and Thomas A D'amico and Mani A. Daneshmand and R Jeffrey G Gaca and Donald D. Glower and Jack Haney and R David Harpole and Mathew G Hartwig and George C Hughes and Jacob A. Klapper and Shu S. Lin and Andrew J. Lodge and Carmelo A. Milano and Ryan P Plichta and Jacob Schr{\"o}der and P Smith and Betty Caroline Tong},
  volume={128 4},
BACKGROUND Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and 1 yr (n = 12); neurocognitive function was assessed at baseline (n = 40), 6 weeks… CONTINUE READING
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