18F-Fluorosulfate for PET Imaging of the Sodium-Iodide Symporter: Synthesis and Biologic Evaluation In Vitro and In Vivo.

@article{Khoshnevisan201718FFluorosulfateFP,
  title={18F-Fluorosulfate for PET Imaging of the Sodium-Iodide Symporter: Synthesis and Biologic Evaluation In Vitro and In Vivo.},
  author={Alex Khoshnevisan and Krisanat Chuamsaamarkkee and Mehdi Boudjemeline and Alex Jackson and Gareth E. Smith and Antony D. Gee and G O Fruhwirth and Philip J Blower},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2017},
  volume={58 1},
  pages={156-161}
}
Anion transport by the human sodium-iodide symporter (hNIS) is an established target for molecular imaging and radionuclide therapy. Current radiotracers for PET of hNIS expression are limited to 124I- and 18F-BF4- We sought new 18F-labeled hNIS substrates offering higher specific activity, higher affinity, and simpler radiochemical synthesis than 18F-BF4- METHODS: The ability of a range of anions, some containing fluorine, to block 99mTcO4- uptake in hNIS-expressing cells was measured. SO3F… CONTINUE READING
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