18F-FDG PET Imaging of Murine Atherosclerosis: Association with Gene Expression of Key Molecular Markers

@article{Hag201218FFDGPI,
  title={18F-FDG PET Imaging of Murine Atherosclerosis: Association with Gene Expression of Key Molecular Markers},
  author={Anne Mette Fisker Hag and Sune Folke Pedersen and Christina Christoffersen and Tina Binderup and Mette Jensen and Jesper Tranekj{\ae}r J{\o}rgensen and Dorthe Charlotte Skovgaard and Rasmus Sejersten Ripa and Andreas Kjaer},
  journal={PLoS ONE},
  year={2012},
  volume={7}
}
Aim To study whether 18F-FDG can be used for in vivo imaging of atherogenesis by examining the correlation between 18F-FDG uptake and gene expression of key molecular markers of atherosclerosis in apoE−/− mice. Methods Nine groups of apoE−/− mice were given normal chow or high-fat diet. At different time-points, 18F-FDG PET/contrast-enhanced CT scans were performed on dedicated animal scanners. After scans, animals were euthanized, aortas removed, gamma counted, RNA extracted from the tissue… Expand
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