18F-5-Fluoroaminosuberic Acid as a Potential Tracer to Gauge Oxidative Stress in Breast Cancer Models

@article{Yang201718F5FluoroaminosubericAA,
  title={18F-5-Fluoroaminosuberic Acid as a Potential Tracer to Gauge Oxidative Stress in Breast Cancer Models},
  author={Hua Yang and Silvia Jenni and Milena {\vC}olovi{\'c} and Helen Merkens and Carlee Poleschuk and Isabel Rodrigo and Qing Miao and Bruce F Johnson and Michael James Rishel and Vesna Sossi and Jack M. Webster and François B{\'e}nard and Paul Schaffer},
  journal={The Journal of Nuclear Medicine},
  year={2017},
  volume={58},
  pages={367 - 373}
}
The cystine transporter (system xC−) is an antiporter of cystine and glutamate. It has relatively low basal expression in most tissues and becomes upregulated in cells under oxidative stress (OS) as one of the genes expressed in response to the antioxidant response element promoter. We have developed 18F-5-fluoroaminosuberic acid (FASu), a PET tracer that targets system xC−. The goal of this study was to evaluate 18F-FASu as a specific gauge for system xC− activity in vivo and its potential for… 
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