188Re(CO)3-dipicolylamine-alendronate: a new bisphosphonate conjugate for the radiotherapy of bone metastases.

  title={188Re(CO)3-dipicolylamine-alendronate: a new bisphosphonate conjugate for the radiotherapy of bone metastases.},
  author={Rafael Torres Mart{\'i}n de Rosales and Ciara Finucane and Julie Gastier Foster and Stephen John Mather and Philip J Blower},
  journal={Bioconjugate chemistry},
  volume={21 5},
The palliation of pain due to bone metastases using targeted compounds containing beta-emitters such as rhenium-188 ((188)Re) is an accepted and effective form of treatment. Here, we describe the efficient synthesis and preclinical evaluation of (188)Re(CO)(3)-dipicolylamine(DPA)-alendronate, a novel bifunctional bisphosphonate for the palliative treatment of bone metastases. (188)Re(CO)(3)-DPA-alendronate can be easily synthesized with high specific activities and yields (18.8 GBq/mg… CONTINUE READING
Highly Cited
This paper has 33 citations. REVIEW CITATIONS
12 Citations
0 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…