1814: SPHINGOSINE KINASE 1 INHIBITION IMPROVES SEPSIS VIA SUPPRESSION OF NLRP3 INFLAMMASOME OF MACROPHAGES

@article{Zhong20191814SK,
  title={1814: SPHINGOSINE KINASE 1 INHIBITION IMPROVES SEPSIS VIA SUPPRESSION OF NLRP3 INFLAMMASOME OF MACROPHAGES},
  author={Ming Zhong and Wei Wu and Yingqin Wang and Jieqiong Song and Hailei Mao and Duming Zhu},
  journal={Critical Care Medicine},
  year={2019},
  volume={47},
  pages={880}
}
Learning Objectives: Although the mortality of sepsis remains high, targeted therapeutic approach is still scarce. Recent studies imply sphingosine kinase 1 (SK1) may play a crucial role in inflammation during sepsis. This research is aimed to investigate the effect of PF-543, a novel highly-selective inhibitor for SK1, on cecal ligation and puncture-induced sepsis and its’ potential mechanism in mice. Methods: This is a bench study in an university laboratory. C57BL/6J, Casp1 and Nlrp3 mice… CONTINUE READING