18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats

@article{Glick199618MethoxycoronaridineAN,
  title={18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats},
  author={Stanley D. Glick and Martin E. Kuehne and Isabelle M. Maisonneuve and Upul K Bandarage and Helen H. Molinari},
  journal={Brain Research},
  year={1996},
  volume={719},
  pages={29-35}
}
View on Elsevier
puzzlepiece.org
106 Citations
Background Citations
35
Methods Citations
5
Results Citations
4

Figures from this paper

106 Citations

Anti-addictive actions of an iboga alkaloid congener: a novel mechanism for a novel treatment
The potential anti-addictive agent, 18-methoxycoronaridine, blocks the sensitized locomotor and dopamine responses produced by repeated morphine treatment
18‐Methoxycoronaridine (18‐MC) and Ibogaine: Comparison of Antiaddictive Efficacy, Toxicity, and Mechanisms of Action
TLDR
The data suggest that 18‐MC has a narrower spectrum of actions and will have a substantially greater therapeutic index than ibogaine, and is likely to have an active metabolite.
Acute iboga alkaloid effects on extracellular serotonin (5-HT) levels in nucleus accumbens and striatum in rats
Attenuation of the reinforcing efficacy of morphine by 18-methoxycoronaridine.
Mechanisms of Antiaddictive Actions of Ibogaine a
TLDR
The authors' ongoing studies in rats suggest that kappa agonist and NMDA antagonist actions contribute to ibogaine's effects on opioid and stimulant self‐administration, while the serotonergic actions may be more important for ibogane‐induced decreases in alcohol intake.
Interactions between 18-methoxycoronaridine (18-MC) and cocaine: dissociation of behavioural and neurochemical sensitization
18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats.
18-Methoxycoronardine attenuates nicotine-induced dopamine release and nicotine preferences in rats
TLDR
In an oral model of nicotine self-administration, both ibogaine and 18-MC decreased rats’ preferences for nicotine for at least 24 h, and the results suggest that 18- MC might be the prototype of a new treatment for smoking.
Iboga interactions with psychomotor stimulants: panacea in the paradox?
...
...

References

SHOWING 1-10 OF 45 REFERENCES
Effects of iboga alkaloids on morphine and cocaine self-administration in rats: relationship to tremorigenic effects and to effects on dopamine release in nucleus accumbens and striatum
Effects and aftereffects of ibogaine on morphine self-administration in rats.
Interactions between ibogaine, a potential anti-addictive agent, and morphine: an in vivo microdialysis study.
Inhibitory effects of ibogaine on cocaine self-administration in rats.
NMDA antagonist properties of the putative antiaddictive drug, ibogaine.
TLDR
Findings link the NMDA antagonist actions of ibogaine to a putative "antiaddictive" property of this alkaloid, its ability to reduce the expression of morphine dependence.
Effects of monoamine reuptake inhibitors on cocaine self-administration in rats
  • S. Tella
  • Biology, Medicine
    Pharmacology Biochemistry and Behavior
  • 1995
Identification of a primary metabolite of ibogaine that targets serotonin transporters and elevates serotonin.
Effects of ibogaine on acute signs of morphine withdrawal in rats: Independence from tremor
Local effects of ibogaine on extracellular levels of dopamine and its metabolites in nucleus accumbens and striatum: interactions withd-amphetamine
Properties of ibogaine and its principal metabolite (12-hydroxyibogamine) at the MK-801 binding site of the NMDA receptor complex
...
...