18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats

@article{Glick199618MethoxycoronaridineAN,
  title={18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats},
  author={Stanley D. Glick and Martin E. Kuehne and Isabelle M. Maisonneuve and Upul K Bandarage and Helen H. Molinari},
  journal={Brain Research},
  year={1996},
  volume={719},
  pages={29-35}
}

Figures from this paper

18‐Methoxycoronaridine (18‐MC) and Ibogaine: Comparison of Antiaddictive Efficacy, Toxicity, and Mechanisms of Action
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The data suggest that 18‐MC has a narrower spectrum of actions and will have a substantially greater therapeutic index than ibogaine, and is likely to have an active metabolite.
Mechanisms of Antiaddictive Actions of Ibogaine a
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The authors' ongoing studies in rats suggest that kappa agonist and NMDA antagonist actions contribute to ibogaine's effects on opioid and stimulant self‐administration, while the serotonergic actions may be more important for ibogane‐induced decreases in alcohol intake.
18-Methoxycoronardine attenuates nicotine-induced dopamine release and nicotine preferences in rats
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In an oral model of nicotine self-administration, both ibogaine and 18-MC decreased rats’ preferences for nicotine for at least 24 h, and the results suggest that 18- MC might be the prototype of a new treatment for smoking.
Iboga interactions with psychomotor stimulants: panacea in the paradox?
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