18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats
@article{Glick199618MethoxycoronaridineAN, title={18-Methoxycoronaridine, a non-toxic iboga alkaloid congener: effects on morphine and cocaine self-administration and on mesolimbic dopamine release in rats}, author={Stanley D. Glick and Martin E. Kuehne and Isabelle M. Maisonneuve and Upul K Bandarage and Helen H. Molinari}, journal={Brain Research}, year={1996}, volume={719}, pages={29-35} }
106 Citations
Anti-addictive actions of an iboga alkaloid congener: a novel mechanism for a novel treatment
- Biology, PsychologyPharmacology Biochemistry and Behavior
- 2003
The potential anti-addictive agent, 18-methoxycoronaridine, blocks the sensitized locomotor and dopamine responses produced by repeated morphine treatment
- Biology, PsychologyBrain Research
- 2000
18‐Methoxycoronaridine (18‐MC) and Ibogaine: Comparison of Antiaddictive Efficacy, Toxicity, and Mechanisms of Action
- BiologyAnnals of the New York Academy of Sciences
- 2000
The data suggest that 18‐MC has a narrower spectrum of actions and will have a substantially greater therapeutic index than ibogaine, and is likely to have an active metabolite.
Acute iboga alkaloid effects on extracellular serotonin (5-HT) levels in nucleus accumbens and striatum in rats
- BiologyBrain Research
- 1998
Attenuation of the reinforcing efficacy of morphine by 18-methoxycoronaridine.
- Biology, ChemistryEuropean journal of pharmacology
- 1999
Mechanisms of Antiaddictive Actions of Ibogaine a
- Biology, PsychologyAnnals of the New York Academy of Sciences
- 1998
The authors' ongoing studies in rats suggest that kappa agonist and NMDA antagonist actions contribute to ibogaine's effects on opioid and stimulant self‐administration, while the serotonergic actions may be more important for ibogane‐induced decreases in alcohol intake.
Interactions between 18-methoxycoronaridine (18-MC) and cocaine: dissociation of behavioural and neurochemical sensitization
- Biology, ChemistryBrain Research
- 2000
18-Methoxycoronaridine acts in the medial habenula and/or interpeduncular nucleus to decrease morphine self-administration in rats.
- Biology, PsychologyEuropean journal of pharmacology
- 2006
18-Methoxycoronardine attenuates nicotine-induced dopamine release and nicotine preferences in rats
- Biology, ChemistryPsychopharmacology
- 1998
In an oral model of nicotine self-administration, both ibogaine and 18-MC decreased rats’ preferences for nicotine for at least 24 h, and the results suggest that 18- MC might be the prototype of a new treatment for smoking.
Iboga interactions with psychomotor stimulants: panacea in the paradox?
- Biology, PsychologyToxicon : official journal of the International Society on Toxinology
- 2001
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