[18-Hydroxycorticosterone, 18-hydroxydesoxycorticosterone. Why, when, how to determine plasma levels in some adrenal pathologies].

Abstract

The authors review some current ideas concerning the role of 18-hydroxylated corticosteroids as mineralocorticoids themselves and as possible precursors of the principal mineralocorticoid, aldosterone. In particular, the physiological and pharmacological agents affecting their secretion are discussed together with a description of the methods used for their analysis in plasma in the department of Clinical Biochemistry Pitié-Salpétrière. Finally, the value of these assays in the differential diagnosis of mineralocorticoid hypertension and inborn errors of corticosteroid biosynthesis is assessed and the constraints on sampling technique listed.

Cite this paper

@article{Aupetit199018Hydroxycorticosterone1W, title={[18-Hydroxycorticosterone, 18-hydroxydesoxycorticosterone. Why, when, how to determine plasma levels in some adrenal pathologies].}, author={Bernard Aupetit and Robert Fraser and Paul Vecsei and M Z{\'e}natti and Sabina Lewicka and Pierre Corvol and N L Zaugg and J. C. Legrand}, journal={Annales d'endocrinologie}, year={1990}, volume={51 1}, pages={1-15} }