18‐MC acts in the medial habenula and interpeduncular nucleus to attenuate dopamine sensitization to morphine in the nucleus accumbens

@article{Taraschenko200718MCAI,
  title={18‐MC acts in the medial habenula and interpeduncular nucleus to attenuate dopamine sensitization to morphine in the nucleus accumbens},
  author={Olga Taraschenko and Joseph M. Shulan and Isabelle M. Maisonneuve and Stanley D. Glick},
  journal={Synapse},
  year={2007},
  volume={61}
}
18‐Methoxycoronaridine (18‐MC), a novel iboga alkaloid congener, is a potential treatment for drug addiction. 18‐MC has been shown to decrease self‐administration of drugs (e.g., morphine, methamphetamine, nicotine) and attenuate opioid withdrawal in rats. In previous studies, systemic pretreatment with 18‐MC abolished the sensitized increase in accumbens dopamine levels induced by chronic morphine administration. In vitro studies have shown that 18‐MC is a potent antagonist of α3β4 nicotinic… 
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TLDR
It is suggested that a nicotinic antagonist action of 18-MC contributes to its putative anti-addictive efficacy and is least effective in decreasing methamphetamine self-administration and most potent in decreasing nicotine self-Administration.
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