18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes.

@article{Shetty201118glycyrrhetinicAT,
  title={18α-glycyrrhetinic acid targets prostate cancer cells by down-regulating inflammation-related genes.},
  author={Aditya Vittal Shetty and Sivasakthivel Thirugnanam and Gajalakshmi Dakshinamoorthy and Abhilash Samykutty and Guoxing Zheng and Aoshuang Chen and Maarten C. Bosland and ANDR{\'E} CARLOS KAJDACSY-BALLA and Munirathinam Gnanasekar},
  journal={International journal of oncology},
  year={2011},
  volume={39 3},
  pages={635-40}
}
Glycyrrhetinic acid is an active triterpenoid metabolite of glycyrrhizin abundantly present in licorice roots. Glycyrrhetinic acid exists as α and β stereo-isomeric forms. Both stereo-isomeric forms are known to have anti-inflammatory and anticancer activity. However, the effects and anticancer mechanism of α glycyrrhetinic acid in prostate cancer cells has not yet been evaluated. Therefore, we investigated the growth inhibition, induction of apoptosis and the anticancer mechanisms of 18… CONTINUE READING

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