17q12-21 - the pursuit of targeted therapy in breast cancer.

  title={17q12-21 - the pursuit of targeted therapy in breast cancer.},
  author={Ronan W Glynn and Nichol L. G. Miller and Michael John Kerin},
  journal={Cancer treatment reviews},
  volume={36 3},
PURPOSE Identification of HER2/neu, and the subsequent development of targeted therapy for patients who over-express it, has revolutionized their management. Research has since focused on the area of chromosome 17 in which HER2/neu is located in order to identify other genes in the vicinity. The aims of this review are, firstly, to discuss current thinking in relation to the role of these genes in the pathogenesis of breast cancer and, secondly, to examine how this evidence may be assimilated… CONTINUE READING


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