17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus.

  title={17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus.},
  author={Patricia C. Galipeau and David S M Cowan and Carissa A. Sanchez and Michael T. Barrett and Mary J. Emond and Douglas S. Levine and Peter S. Rabinovitch and Brian J. Reid},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 14},
Increased 4N (G2/tetraploid) cell populations have been postulated to be genetically unstable intermediates in the progression to many cancers, but the mechanism by which they develop and their relationship to instability have been difficult to investigate in humans in vivo. Barrett's esophagus is an excellent model system in which to investigate the order in which genetic and cell cycle abnormalities develop relative to each other during human neoplastic progression. Neoplastic progression in… CONTINUE READING

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