17beta-estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brain.

@article{Gerstner200917betaestradiolPA,
  title={17beta-estradiol protects against hypoxic/ischemic white matter damage in the neonatal rat brain.},
  author={Bettina Gerstner and Joan Lee and Tara M Desilva and Frances E. Jensen and Joseph J. Volpe and Paul A. Rosenberg},
  journal={Journal of neuroscience research},
  year={2009},
  volume={87 9},
  pages={2078-86}
}
Developing oligodendrocytes (pre-OLs) are highly vulnerable to hypoxic-ischemic injury and associated excitotoxicity and oxidative stress. 17beta-Estradiol plays an important role in the development and function of the CNS and is neuroprotective. The sudden drop in circulating estrogen after birth may enhance the susceptibility of developing OLs to injury. Estrogen receptor (ER)-alpha and ER-beta are both expressed in OLs. We examined the effect of 17beta-estradiol on oxygen-glucose deprivation… CONTINUE READING

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