17beta-estradiol promotes the odonto/osteogenic differentiation of stem cells from apical papilla via mitogen-activated protein kinase pathway

@inproceedings{Li201417betaestradiolPT,
  title={17beta-estradiol promotes the odonto/osteogenic differentiation of stem cells from apical papilla via mitogen-activated protein kinase pathway},
  author={Yao Li and Ming Yan and Yang Zheng and Yangyu Zheng and Junjun Li and Shu Ma and Genxia Liu and Jinhua Yu},
  booktitle={Stem Cell Research & Therapy},
  year={2014}
}
IntroductionEstrogen plays an important role in the osteogenic differentiation of mesenchymal stem cells, while stem cells from apical papilla (SCAP) can contribute to the formation of dentin/bone-like tissues. To date, the effects of estrogen on the differentiation of SCAP remain unclear.MethodsSCAP was isolated and treated with 10-7 M 17beta-estradiol (E2). The odonto/osteogenic potency and the involvement of mitogen-activated protein kinase (MAPK) signaling pathway were subsequently… CONTINUE READING
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