17beta-estradiol does not protect cerebellar granule cells from excitotoxicity or apoptosis.

@article{Miano200717betaestradiolDN,
  title={17beta-estradiol does not protect cerebellar granule cells from excitotoxicity or apoptosis.},
  author={Alfredo Mi{\~n}ano and Marco Cerb{\'o}n and Xavier Xifr{\'o} and Cristina Malagelada and Jos{\'e} Aguilera and Jos{\'e} Rodr{\'i}guez-{\'A}lvarez},
  journal={Journal of neurochemistry},
  year={2007},
  volume={102 2},
  pages={354-64}
}
Mounting evidences have suggested that 17beta-estradiol (E2) could have a neuroprotective action in the CNS. In the present study, we wanted to study whether this estrogen was able to protect cerebellar granule cells (CGCs) from apoptosis or excitotoxicity. Our results suggest that E2 has no anti-apoptotic effect in CGCs cultures. The lack of phosphoinositide 3-kinase/Akt pathway activation in CGCs cultures could be on the basis of the failure of estradiol to protect CGCs from potassium… CONTINUE READING

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