17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease.

@article{MiyazakiAkita200717betaestradiolAT,
  title={17beta-estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: relevance to postmenopausal diabetic cardiovascular disease.},
  author={Asaka Miyazaki-Akita and Toshio Hayashi and Qun Fang Ding and Hiroaki Shiraishi and Takahide Nomura and Yuichi Hattori and Akihisa Iguchi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2007},
  volume={320 2},
  pages={591-8}
}
In postmenopausal women, the risk of diabetic cardiovascular disease drastically increases compared with that of men or premenopausal women. However, the mechanism of this phenomenon has not yet been clarified. We hypothesized that the beneficial effects of estrogen on endothelial function may be relevant to protection against hyperglycemia-induced vascular derangement. Bovine aortic endothelial cells were incubated for 72 h in the presence and absence of the physiological concentration of… CONTINUE READING