17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells.


Nucleotide excision repair (NER) is the primary mechanism that removes bulky DNA adducts such as those caused by ubiquitous environmental mutagens including benzo(a)pyrene and other polycyclic aromatic hydrocarbons. Recent data suggest that exposure to environmentally relevant concentrations of estrogen decreases hepatic mRNA abundance of several key NER… (More)
DOI: 10.1016/j.aquatox.2009.01.001


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