17Beta-estradiol inhibits high-voltage-activated calcium channel currents in rat sensory neurons via a non-genomic mechanism.

@article{Lee200217BetaestradiolIH,
  title={17Beta-estradiol inhibits high-voltage-activated calcium channel currents in rat sensory neurons via a non-genomic mechanism.},
  author={Dong Yun Lee and Young Gyu Chai and Eunhee Lee and Ki Whan Kim and Seung-yeol Nah and Tae Hwan Oh and Hyewhon Rhim},
  journal={Life sciences},
  year={2002},
  volume={70 17},
  pages={
          2047-59
        }
}
There is increasing evidence that estrogen influences electrical activity of neurons via stimulation of membrane receptors. Although the presence of intracellular estrogen receptors and their responsiveness in dorsal root ganglion (DRG) primary sensory neurons were reported, rapid electrical responses of estrogen in DRG neurons have not been reported yet. Therefore the current study was initiated to examine the rapid effects of estrogen on Ca2+ channels and to determine its detailed mechanism… CONTINUE READING