17Beta-estradiol enhances the production of nerve growth factor in THP-1-derived macrophages or peripheral blood monocyte-derived macrophages.

@article{Kanda200317BetaestradiolET,
  title={17Beta-estradiol enhances the production of nerve growth factor in THP-1-derived macrophages or peripheral blood monocyte-derived macrophages.},
  author={Naoko Kanda and Shinichi Watanabe},
  journal={The Journal of investigative dermatology},
  year={2003},
  volume={121 4},
  pages={
          771-80
        }
}
We examined in vitro effects of 17beta-estradiol (E2) on nerve growth factor production by macrophages derived from monocytic cell line THP-1-or periphereal blood monocytes. E2 and membrane-impermeable bovine serum albumin-conjugated E2 (E2-BSA) enhanced nerve growth factor secretion and mRNA expression in both types of macrophages E2 enhanced nerve growth factor promotor activity in THP-1-derived macrophages and two activator protein-1 binding sites on the promoter were responsible for the… CONTINUE READING
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