17Beta-estradiol, its metabolites, and progesterone inhibit cardiac fibroblast growth.

  title={17Beta-estradiol, its metabolites, and progesterone inhibit cardiac fibroblast growth.},
  author={Raghvendra K Dubey and Delbert G. Gillespie and Edwin K Jackson and Paul J. Keller},
  volume={31 1 Pt 2},
Postmenopausal women (PMW) have increased incidence of cardiovascular disease, and estrogen substitution therapy has been shown to have cardioprotective effects. Since abnormal growth of cardiac fibroblasts (CFs) is associated with hypertension and myocardial infarction and estrogen inhibits vascular smooth muscle cell (SMC) growth, it is feasible that estrogen may attenuate cardiac remodeling by inhibiting CF growth, and this possibility was investigated by using cultured CFs. 17Beta-estradiol… CONTINUE READING
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