177 Exposure of Bovine Oocytes to a Residual Concentration of Mono-(2-ethylhexyl) Phthalate Further Impairs Blastocyst Gene Expression.

@article{Roth2016177EO,
  title={177 Exposure of Bovine Oocytes to a Residual Concentration of Mono-(2-ethylhexyl) Phthalate Further Impairs Blastocyst Gene Expression.},
  author={Zvi N Roth and Dorit Kalo},
  journal={Reproduction, fertility, and development},
  year={2016},
  volume={29 1},
  pages={197}
}
Di-(2-ethylhexyl) phthalate and its metabolite, mono-(2-ethylhexyl) phthalate (MEHP), are reproductive toxicants. We recently documented a residual concentration of MEHP (~20 nM) and a 2-fold lower level of oestradiol in preovulatory-follicular fluid aspirated from cows gavaged with di-(2-ethylhexyl) phthalate (100mg/kg/day; 3 days). To examine the effects of these changes on oocyte developmental competence, cumulus-oocyte complexes (COC; n=3290; 14 replicates) were in vitro matured (22h) in… CONTINUE READING