175 – Pathogenesis and pathology of osteoarthritis

@inproceedings{Aigner2015175P,
  title={175 – Pathogenesis and pathology of osteoarthritis},
  author={Thomas Aigner and Nicole Schmitz and Donald Salter},
  year={2015}
}
The Future of Cartilage Repair
TLDR
Some current treatments and the emerging strategies/techniques employed by researchers and physicians thriving to repair articular cartilage through biological means are discussed, as two stage procedures involving cell culture are expensive and cumbersome.
WHY BASIC CALCIUM PHOSPHATE CRYSTALS SHOULD BE TARGETED IN THE TREATMENT OF OSTEOARTHRITIS
TLDR
Why basic calcium crystals are important in the pathogenesis of OA is focused on and there is ample evidence that BCP crystals should be explored as a therapeutic target in OA.
Transdermal bio-identical progesterone cream as hormonal treatment for osteoarthritis.
TLDR
Transdermal bio-identical progesterone cream as suggested hormonal treatment of OA is discussed, based on its pathogenic process, which may indirectly regulate bone remodeling and may also play a role in the development and maintenance of cartilage.
Isokinetic test and exercises in knee osteoarthritis
TLDR
Authors, arguing that quadriceps muscle weakness has a deteriorating affect on knee osteoarthritis, also come to a conclusion that strengthening this muscle has a beneficial effect on knee arthritis.
Estrogen alleviates post-traumatic osteoarthritis progression and decreases p-EGFR levels in female mouse cartilage
TLDR
Estrogen has a regulatory effect on PTOA and its inhibits the expression of p-EGFR in cartilage on the knee joint surface and has a protective effect on articular cartilage in female mice.
Cervical Vertebral Trabecular Bone Mineral Density in Great Danes With and Without Osseous‐Associated Cervical Spondylomyelopathy
TLDR
No association was detected between cervical OA and BMD in GDs with CSM and control dogs, and no difference in BMD between control and CSM‐affected GDs was revealed.
Oral Versus Topical Diclofenac Sodium in the Treatment of Osteoarthritis
TLDR
Clinicians that currently must decide between very inexpensive diclofenac oral presentations and expensive topical presentations especially in the elderly population are suggested to consider the pros and cons of such decision-making process.
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TLDR
Evidence suggests that cell aging is important in the pathogenesis of osteoarthritis, and anti-aging strategies might complement existing therapeutic targets related to anabolism, catabolicism, inflammation, and apoptosis—processes that are integral to the pathogenic of osteOarthritis.
Reviewing knee osteoarthritis--a biomechanical perspective.
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TLDR
It is shown that in all cases of clinically overt osteoarthritic joint disease significant synovial pathology is associated and this is suggestive of a distinct pathogenetic role of the synovium also in osteoartritic cartilage degeneration at least in a subset of cases.
Osteoarthritis and nitric oxide.
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TLDR
There is an inverse relationship between cell density and the thickness of articular cartilage and the findings are relevant to the nutrition and to some aspects of the growth and pathology of the tissue.
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TLDR
This study is the most comprehensive analysis of the metzincin family of proteinases in the joint to date and has identified several proteinase genes not previously reported to be expressed or regulated in synovium.
Molecular targets in osteoarthritis: metalloproteinases and their inhibitors.
TLDR
The concept of molecular polypharmacy, in which the relevant enzymes are selectively targeted with multiple directed therapies, may offer a new therapeutic strategy that prevents joint destruction and minimizes toxicities.
Severe disturbance of the distribution and expression of type VI collagen chains in osteoarthritic articular cartilage.
TLDR
It is suggested that there is a significant basic turnover of type VI collagen in normal articular cartilage and in OA cartilage, the chondrocytes of the lower middle and upper deep zones account for a net increase intype VI collagen synthesis.
Extracellular matrix changes regulate calcium crystal formation in articular cartilage.
PURPOSE OF REVIEW The pathologic matrix mineralization seen in calcium pyrophosphate dihydrate and basic calcium phosphate deposition diseases identifies a subset of osteoarthritis patients with an
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