The Future of Cartilage Repair
- Medicine, BiologyPersonalized Medicine in Healthcare Systems
Some current treatments and the emerging strategies/techniques employed by researchers and physicians thriving to repair articular cartilage through biological means are discussed, as two stage procedures involving cell culture are expensive and cumbersome.
Degenerative osteoarthritis a reversible chronic disease
- MedicineRegenerative therapy
WHY BASIC CALCIUM PHOSPHATE CRYSTALS SHOULD BE TARGETED IN THE TREATMENT OF OSTEOARTHRITIS
Why basic calcium crystals are important in the pathogenesis of OA is focused on and there is ample evidence that BCP crystals should be explored as a therapeutic target in OA.
Transdermal bio-identical progesterone cream as hormonal treatment for osteoarthritis.
- Biology, MedicineActa medica Indonesiana
Transdermal bio-identical progesterone cream as suggested hormonal treatment of OA is discussed, based on its pathogenic process, which may indirectly regulate bone remodeling and may also play a role in the development and maintenance of cartilage.
Integrin α1β1 protects against signs of post-traumatic osteoarthritis in the female murine knee partially via regulation of epidermal growth factor receptor signalling.
- Biology, MedicineOsteoarthritis and cartilage
Isokinetic test and exercises in knee osteoarthritis
Authors, arguing that quadriceps muscle weakness has a deteriorating affect on knee osteoarthritis, also come to a conclusion that strengthening this muscle has a beneficial effect on knee arthritis.
Colchicine treatment in adult patients with knee osteoarthritis: Systematic review of the literature
Estrogen alleviates post-traumatic osteoarthritis progression and decreases p-EGFR levels in female mouse cartilage
- BiologyBMC Musculoskeletal Disorders
Estrogen has a regulatory effect on PTOA and its inhibits the expression of p-EGFR in cartilage on the knee joint surface and has a protective effect on articular cartilage in female mice.
Cervical Vertebral Trabecular Bone Mineral Density in Great Danes With and Without Osseous‐Associated Cervical Spondylomyelopathy
- Medicine, BiologyJournal of veterinary internal medicine
No association was detected between cervical OA and BMD in GDs with CSM and control dogs, and no difference in BMD between control and CSM‐affected GDs was revealed.
Oral Versus Topical Diclofenac Sodium in the Treatment of Osteoarthritis
- MedicineJournal of pain & palliative care pharmacotherapy
Clinicians that currently must decide between very inexpensive diclofenac oral presentations and expensive topical presentations especially in the elderly population are suggested to consider the pros and cons of such decision-making process.
SHOWING 1-10 OF 55 REFERENCES
Cartilage degeneration in different human joints.
- Biology, EngineeringOsteoarthritis and cartilage
Mechanisms of Disease: role of chondrocytes in the pathogenesis of osteoarthritis—structure, chaos and senescence
- Biology, MedicineNature Clinical Practice Rheumatology
Evidence suggests that cell aging is important in the pathogenesis of osteoarthritis, and anti-aging strategies might complement existing therapeutic targets related to anabolism, catabolicism, inflammation, and apoptosis—processes that are integral to the pathogenic of osteOarthritis.
Reviewing knee osteoarthritis--a biomechanical perspective.
- Medicine, BiologyJournal of science and medicine in sport
Subtyping of osteoarthritic synoviopathy.
- Medicine, BiologyClinical and experimental rheumatology
It is shown that in all cases of clinically overt osteoarthritic joint disease significant synovial pathology is associated and this is suggestive of a distinct pathogenetic role of the synovium also in osteoartritic cartilage degeneration at least in a subset of cases.
The interrelationship of cell density and cartilage thickness in mammalian articular cartilage.
- BiologyJournal of anatomy
There is an inverse relationship between cell density and the thickness of articular cartilage and the findings are relevant to the nutrition and to some aspects of the growth and pathology of the tissue.
Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage
- BiologyArthritis research & therapy
This study is the most comprehensive analysis of the metzincin family of proteinases in the joint to date and has identified several proteinase genes not previously reported to be expressed or regulated in synovium.
Molecular targets in osteoarthritis: metalloproteinases and their inhibitors.
- BiologyCurrent drug targets
The concept of molecular polypharmacy, in which the relevant enzymes are selectively targeted with multiple directed therapies, may offer a new therapeutic strategy that prevents joint destruction and minimizes toxicities.
Severe disturbance of the distribution and expression of type VI collagen chains in osteoarthritic articular cartilage.
- Medicine, BiologyArthritis and rheumatism
It is suggested that there is a significant basic turnover of type VI collagen in normal articular cartilage and in OA cartilage, the chondrocytes of the lower middle and upper deep zones account for a net increase intype VI collagen synthesis.
Extracellular matrix changes regulate calcium crystal formation in articular cartilage.
- MedicineCurrent opinion in rheumatology
PURPOSE OF REVIEW The pathologic matrix mineralization seen in calcium pyrophosphate dihydrate and basic calcium phosphate deposition diseases identifies a subset of osteoarthritis patients with an…