17-hydroxylation deficiency in man.

  title={17-hydroxylation deficiency in man.},
  author={Edward G. Biglieri and M A Herron and N Brust},
  journal={The Journal of clinical investigation},
  volume={45 12},
The biosynthesis of steroid hormones 1 requires a number of hydroxylating enzymes. Deficiency of these enzymes is demonstrated by increased or decreased amounts of certain steroid metabolites in blood and urine and is best exemplified by the deficiency of 11,8-hydroxylase (1) and 21-hy-droxylase (2) in patients with congenital adrenal hyperplasia. 17a-Hydroxylase activity is present in these disorders because of the increases in secretion of androgens and excretion of preg-nanetriol. In… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 74 extracted citations


Publications referenced by this paper.
Showing 1-10 of 19 references

Chromatographie d ' adsorption sur papier des acetates de st eroides peu polaires

  • J. R. Pasqualini
  • J . clin . Invest .
  • 1963

The effects of chorionic gonadotropin in adult men : increased estrogen and 17ketosteroid excretion , gynecomastia , Leydig cell stimulation and seminiferous tubule damage

  • W. O. Maddock
  • J . biol . Chem .
  • 1962

Assay of the follicle stimulating hormone based on the augmentation with human chorionic gonadotropin

  • S. L. Steelman
  • J . clin . Invest .
  • 1960

Meta - bolic effects in man of orally and parenterally administered corticosterone ( compound B )

  • J. W. Conn
  • Scand . J . clin . Lab . Invest .
  • 1960

Similar Papers

Loading similar papers…