17-hydroxylation deficiency in man.

@article{Biglieri196617hydroxylationDI,
  title={17-hydroxylation deficiency in man.},
  author={Edward G. Biglieri and M A Herron and N Brust},
  journal={The Journal of clinical investigation},
  year={1966},
  volume={45 12},
  pages={1946-54}
}
The biosynthesis of steroid hormones 1 requires a number of hydroxylating enzymes. Deficiency of these enzymes is demonstrated by increased or decreased amounts of certain steroid metabolites in blood and urine and is best exemplified by the deficiency of 11,8-hydroxylase (1) and 21-hy-droxylase (2) in patients with congenital adrenal hyperplasia. 17a-Hydroxylase activity is present in these disorders because of the increases in secretion of androgens and excretion of preg-nanetriol. In… CONTINUE READING

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