17 beta-estradiol is the most active component of the conjugated estrogen mixture active on uremic bleeding by a receptor mechanism.

@article{Vigan199017BI,
  title={17 beta-estradiol is the most active component of the conjugated estrogen mixture active on uremic bleeding by a receptor mechanism.},
  author={G L Vigan{\`o} and Carlamaria Zoja and Daniela Corna and Michele Rossini and F. Pusineri and Silvio Garattini and Giuseppe Remuzzi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1990},
  volume={252 1},
  pages={
          344-8
        }
}
We have reported previously that a mixture of conjugated estrogens which is effective in shortening the prolonged bleeding time in uremic patients is also effective on bleeding time in a rat model of uremia. With the present study we took advantage from such a rat model of chronic uremia and decided to identify the component(s) of the conjugated estrogen mixture responsible for shortening the bleeding time. Moreover, we wanted to clarify whether estrogen effect on primary hemostasis is due to a… CONTINUE READING