17-beta estradiol independently regulates erythropoietin synthesis and NOS activity during hypoxia.

@article{Mukundan200417betaEI,
  title={17-beta estradiol independently regulates erythropoietin synthesis and NOS activity during hypoxia.},
  author={Harshini Mukundan and Thomas C. Resta and Nancy Lapp Kanagy},
  journal={Journal of cardiovascular pharmacology},
  year={2004},
  volume={43 2},
  pages={
          312-7
        }
}
We reported previously that 17-beta estradiol (E2-beta) attenuates hypoxic induction of erythropoietin (EPO) synthesis in rats. We hypothesized this attenuation is mediated by increased nitric oxide (NO) bio-availability. To investigate this hypothesis, ovariectomized estrogen-depleted rats were instrumented with arterial and venous catheters and treated with either E2-beta (20 microg/24 hrs) or vehicle (polypropylene glycol) for 7 days. Rats were placed in Plexiglas boxes and administered a… CONTINUE READING
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