17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.

  title={17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1.},
  author={C L Hayes and David C. Spink and Barbara C. Spink and Jefferey Q Cao and Nigel J. Walker and Thomas R. Sutter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 18},
The 4-hydroxy metabolite of 17 beta-estradiol (E2) has been implicated in the carcinogenicity of this hormone. Previous studies showed that aryl hydrocarbon-receptor agonists induced a cytochrome P450 that catalyzed the 4-hydroxylation of E2. This activity was associated with human P450 1B1. To determine the relationship of the human P450 1B1 gene product and E2 4-hydroxylation, the protein was expressed in Saccharomyces cerevisiae. Microsomes from the transformed yeast catalyzed the 4- and 2… CONTINUE READING
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