17-beta-estradiol analog inhibits cell proliferation by induction of apoptosis in breast cell lines.

@article{Visagie201417betaestradiolAI,
  title={17-beta-estradiol analog inhibits cell proliferation by induction of apoptosis in breast cell lines.},
  author={Michelle Helen Visagie and Lynn-Marie Birkholtz and Annie Margaretha Joubert},
  journal={Microscopy research and technique},
  year={2014},
  volume={77 3},
  pages={
          236-42
        }
}
Microtubules are important targets when studying potential anticancer agents since disturbance of these microtubule dynamics results in cell cycle arrest and cell death. 2-Methoxyestradiol is a naturally occurring metabolite that exerts antiproliferative activity and induces apoptosis. Due to limited biological accessibly and rapid metabolic degradation, several analogs were synthesized. This study investigated the antiproliferative influence of an 2-methoxyestradiol analog, (8R, 13S, 14S, 17S… CONTINUE READING
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