17 beta-Hydroxysteroid dehydrogenase type 1 and type 2 in ductal carcinoma in situ and intraductal proliferative lesions of the human breast.

@article{Ariga200017BD,
  title={17 beta-Hydroxysteroid dehydrogenase type 1 and type 2 in ductal carcinoma in situ and intraductal proliferative lesions of the human breast.},
  author={Naohiro Ariga and Takuya Moriya and Takashi Suzuki and M. Kimura and Noriaki Ohuchi and Susumu Satomi and Hironobu Sasano},
  journal={Anticancer research},
  year={2000},
  volume={20 2B},
  pages={1101-8}
}
17 beta-hydroxysteroid dehydrogenases (17 beta-HSDs) are involved in the interconversion of biologically active and inactive sex steroids and are considered to play important roles in the in situ metabolism of estrogen in various estrogen dependent tissues. 17 beta-HSD type 1 catalyzes primarily the reduction of estrone (E1) to estradiol (E2), whereas 17 beta-HSD type 2 catalyzes primarily the oxidation of E2 to E1. However, the possible biological roles of these estrogen metabolizing isozymes… CONTINUE READING