17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells.

  title={17 alpha-estradiol exerts neuroprotective effects on SK-N-SH cells.},
  author={Pattie S. Green and Jean Bishop and James William Simpkins},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={17 2},
Estradiol (E2) has been shown to exert organizational, neurotrophic, and neuroprotective effects in the CNS. The present study assessed the specificity of the neuroprotective effects of estradiol for the potent 17 beta-isomer. SK-N-SH cells from a human neuroblastoma cell line, which we have shown to be estrogen-responsive, were cultured at low or high plating density. Then cells were exposed to 17 beta-E2 (0.2 or 2 nM), 17 alpha-E2 (0.2 or 2 nM), or cholesterol, testosterone… CONTINUE READING


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