17-Epimerization of 17α-methyl anabolic steroids in humans: metabolism and synthesis of 17α-hydroxy-17β-methyl steroids

@article{Schnzer199217EpimerizationO1,
  title={17-Epimerization of 17$\alpha$-methyl anabolic steroids in humans: metabolism and synthesis of 17$\alpha$-hydroxy-17$\beta$-methyl steroids},
  author={Willi Sch{\"a}nzer and Georg Opfermann and Manfred Donike},
  journal={Steroids},
  year={1992},
  volume={57},
  pages={537-550}
}
New Insights into the Metabolism of Methyltestosterone and Metandienone: Detection of Novel A-Ring Reduced Metabolites
TLDR
The results provide new insights into the metabolism of 17α-methyl steroids with respect to the order of reductions in the A-ring, the participation of different enzymes, and alterations to the D-ring.
New oxymesterone metabolites in human by gas chromatography-tandem mass spectrometry and their application for doping control.
TLDR
Based on the behavior of the MS/MS results of product ion and precursor ion modes, a GC-MS/MS method has been developed monitoring these metabolites and can extend the detection window up to 4 days since the parent steroid was not detectable.
Glucuronidation of anabolic androgenic steroids by recombinant human UDP-glucuronosyltransferases.
TLDR
The high activity of UGT1A8 and 1A10 toward some of the substrates indicates that extrahepatic enzymes might play a role in the metabolism of anabolic androgenic steroids.
Preliminary study of the metabolism of 17 alpha-methyltestosterone in horses utilizing gas chromatography-mass spectrometric techniques.
TLDR
The metabolism of 17 alpha-methyltestosterone is investigated by oral administration of a (1 + 1) mixture of the steroid and its deuteriated analogue using both electron impact and chemical ionization techniques.
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The metabolism of 17 alpha-methyl-17 beta-hydroxy-1,4-androstadien-3-one (dianabol) in human adults has been studied in detail by computer aided capillary gas chromatography mass spectrometry. After
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TLDR
The metabolism of 17 alpha-methyl-17 beta-hydroxy-2-oxa-5 alpha-androstan-3-one (oxandrolone) in man has been investigated by gas chromatography/mass spectrometry and the susceptibility of ox androlone to hydrolysis was investigated under several pH conditions.
GC and capillary column GC/MS determination of synthetic anabolic steroids. II. 4-chloro-methandienone (oral turinabol) and its metabolites.
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