17-Epimerization of 17α-methyl anabolic steroids in humans: metabolism and synthesis of 17α-hydroxy-17β-methyl steroids

@article{Schnzer199217EpimerizationO1,
  title={17-Epimerization of 17$\alpha$-methyl anabolic steroids in humans: metabolism and synthesis of 17$\alpha$-hydroxy-17$\beta$-methyl steroids},
  author={Willi Sch{\"a}nzer and Georg Opfermann and Manfred Donike},
  journal={Steroids},
  year={1992},
  volume={57},
  pages={537-550}
}
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72 Citations
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72 Citations

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Detection of Δ6-methyltestosterone in a "dietary supplement" and GC-MS/MS investigations on its urinary metabolism.
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The high activity of UGT1A8 and 1A10 toward some of the substrates indicates that extrahepatic enzymes might play a role in the metabolism of anabolic androgenic steroids.
Unexpected contribution of cytochrome P450 enzymes CYP11B2 and CYP21, as well as CYP3A4 in xenobiotic androgen elimination - insights from metandienone metabolism.
Preliminary study of the metabolism of 17 alpha-methyltestosterone in horses utilizing gas chromatography-mass spectrometric techniques.
TLDR
The metabolism of 17 alpha-methyltestosterone is investigated by oral administration of a (1 + 1) mixture of the steroid and its deuteriated analogue using both electron impact and chemical ionization techniques.
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References

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