17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells

@inproceedings{Karkoulis201017Allylamino17demethoxygeldanamy,
  title={17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells},
  author={Panagiotis K. Karkoulis and Dimitrios J. Stravopodis and Lukas H. Margaritis and Gerassimos E. Voutsinas},
  booktitle={BMC Cancer},
  year={2010}
}
17-Allylamino-17-demethoxygeldanamycin (17-AAG), a benzoquinone ansamycin antibiotic, specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone that maintains the structural and functional integrity of various protein clients involved in cellular signaling. In this study, we have investigated the effect of 17-AAG on the regulation of Hsp90-dependent signaling pathways directly implicated in cell cycle progression, survival and motility of human… CONTINUE READING
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Voutsinas GE: Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex

  • DJ Stravopodis, LH Margaritis
  • Curr Med Chem
  • 2007
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