17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy

@inproceedings{Riedel201017AAGIC,
  title={17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy},
  author={Michael Riedel and Olaf Goldbaum and Lisa Schwarz and Sebastian W. Schmitt and Christiane Richter-Landsberg},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND The accumulation and aggregation of alpha-synuclein in nerve cells and glia are characteristic features of a number of neurodegenerative diseases termed synucleinopathies. alpha-Synuclein is a highly soluble protein which in a nucleation dependent process is capable of self-aggregation. The causes underlying aggregate formation are not yet understood, impairment of the proteolytic degradation systems might be involved. METHODOLOGY/PRINCIPAL FINDINGS In the present study the… CONTINUE READING
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