17β-estradiol is necessary for extinction of cocaine seeking in female rats.

@article{Twining201317estradiolIN,
  title={17β-estradiol is necessary for extinction of cocaine seeking in female rats.},
  author={Robert C. Twining and Jennifer J. Tuscher and Elizabeth M Doncheck and Karyn M. Frick and Devin Mueller},
  journal={Learning & memory},
  year={2013},
  volume={20 6},
  pages={
          300-6
        }
}
Human and preclinical models of addiction demonstrate that gonadal hormones modulate acquisition of drug seeking. Little is known, however, about the effects of these hormones on extinction of drug-seeking behavior. Here, we investigated how 17β-estradiol (E₂) affects expression and extinction of cocaine seeking in female rats. Using a conditioned place preference (CPP) paradigm, ovariectomized rats were maintained throughout conditioning with 2 d of E₂ treatment followed by 2 d of vehicle… CONTINUE READING

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