17β-estradiol attenuates ovariectomy-induced bone deterioration through the suppression of the ephA2/ephrinA2 signaling pathway

@article{Liu201817estradiolAO,
  title={17$\beta$-estradiol attenuates ovariectomy-induced bone deterioration through the suppression of the ephA2/ephrinA2 signaling pathway},
  author={Lianyong Liu and Lin Zhou and Xiaorong Yang and Qi Liu and Ling Yang and Chaochao Zheng and Yongling Zhao and Zhenlin Zhang and Xiaohong Luo},
  journal={Molecular Medicine Reports},
  year={2018},
  volume={17},
  pages={1609 - 1616}
}
The present study aimed to investigate whether 17β-estradiol (E2) exerts protective effects on bone deterioration induced by ovariectomy (OVX) through the ephA2/ephrinA2 signaling pathway in rats. Female rats were subjected to OVX, sham surgeryor OVX+E2 treatment. Levels of biomarkers were measured in serum and urine. Hematoxylin and eosin staining was performed on paraffin-embedded bone sections. Expression of genes and proteins was analyzed by reverse transcription-quantitative polymerase… 

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