17β-estradiol attenuates glycogen synthase kinase-3β activation and tau hyperphosphorylation in Akt-independent manner

@article{Shi200817estradiolAG,
  title={17β-estradiol attenuates glycogen synthase kinase-3β activation and tau hyperphosphorylation in Akt-independent manner},
  author={Hai-Rong Shi and Ling-Qiang Zhu and Shao-hui Wang and Xin-an Liu and Qing Tian and Qi Zhang and Qun Wang and Jian-Zhi Wang},
  journal={Journal of Neural Transmission},
  year={2008},
  volume={115},
  pages={879-888}
}
Decline of estrogen is associated with high incidence of Alzheimer’s disease (AD) characterized pathologically with tau hyperphosphorylation, and glycogen synthase kinase-3β (GSK-3β) is a major tau kinase. However, the role of estrogen on GSK3β-induced tau hyperphosphorylation is elusive. Here, we treated N2a cells with wortmannin (Wort) and GF-109203X (GFX) or gene transfection to activate GSK-3β and to induce tau hyperphosphorylation and then the effects of 17β-estradiol (βE2) on tau… CONTINUE READING
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