17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development

@article{MarchaisOberwinkler201117HydroxysteroidD,
  title={17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: Protein structures, functions, and recent progress in inhibitor development},
  author={S. Marchais-Oberwinkler and C. Henn and G. M{\"o}ller and Tobias Klein and J. Adamski},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2011},
  volume={125},
  pages={66-82}
}
  • S. Marchais-Oberwinkler, C. Henn, +2 authors J. Adamski
  • Published 2011
  • Biology, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • 17β-Hydroxysteroid dehydrogenases (17β-HSDs) are oxidoreductases, which play a key role in estrogen and androgen steroid metabolism by catalyzing final steps of the steroid biosynthesis. Up to now, 14 different subtypes have been identified in mammals, which catalyze NAD(P)H or NAD(P)(+) dependent reductions/oxidations at the 17-position of the steroid. Depending on their reductive or oxidative activities, they modulate the intracellular concentration of inactive and active steroids. As the… CONTINUE READING
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