17β-Estradiol up-regulates miR-155 expression and reduces TP53INP1 expression in MCF-7 breast cancer cells

@article{Zhang201317EstradiolUM,
  title={17β-Estradiol up-regulates miR-155 expression and reduces TP53INP1 expression in MCF-7 breast cancer cells},
  author={Chunmei Zhang and Jing Zhao and Huayu Deng},
  journal={Molecular and Cellular Biochemistry},
  year={2013},
  volume={379},
  pages={201-211}
}
In estrogen responsive breast cancer cells, estradiol (E2) is a key regulator of cell proliferation and survival. MiR-155 has emerged as an “oncomiR”, which is the most significantly up-regulated miRNA in breast cancer. Moreover, miR-155 is higher in ERα (+) breast tumors than ERα (−), but no one has examined whether E2 regulates miR-155 expression in MCF-7 cells. In this study, the aim was to explore whether miR-155 involved in E2 regulated expression of estrogen responsive genes. We evaluated… CONTINUE READING

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