17β-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes

@inproceedings{Jallow201817EstradiolAI,
  title={17β-Estradiol and ICI182,780 Differentially Regulate STAT5 Isoforms in Female Mammary Epithelium, With Distinct Outcomes},
  author={Fatou Jallow and Jennifer L. Brockman and Kyle T Helzer and Debra E. Rugowski and Vincent Goffin and Elaine T. Alarid and Linda A. Schuler},
  booktitle={Journal of the Endocrine Society},
  year={2018}
}
Prolactin (PRL) and estrogen cooperate in lobuloalveolar development of the mammary gland and jointly regulate gene expression in breast cancer cells in vitro. Canonical PRL signaling activates STAT5A/B, homologous proteins that have different target genes and functions. Although STAT5A/B are important for physiological mammary function and tumor pathophysiology, little is known about regulation of their expression, particularly of STAT5B, and the consequences for hormone action. In this study… CONTINUE READING

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