17β-Estradiol Enhances Vascular Endothelial Ets-1/miR-126-3p Expression: The Possible Mechanism for Attenuation of Atherosclerosis.

@article{Li201717EstradiolEV,
  title={17β-Estradiol Enhances Vascular Endothelial Ets-1/miR-126-3p Expression: The Possible Mechanism for Attenuation of Atherosclerosis.},
  author={Ping Li and Jinzhi Wei and Xiaosa Li and Yang Cheng and Weiyu Chen and Yuhong Cui and Tommaso Simoncini and Zhengtian Gu and Jun Yang and Xiao-Dong Fu},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2017},
  volume={102 2},
  pages={594-603}
}
Context Endothelial microRNA 126 (miR-126) attenuates the development of atherosclerosis (AS). However, there is no evidence showing the role of miR-126 in estrogen's antiatherogenic effects. Objective We hypothesized that 17β-estradiol (E2) modulates miR-126 expression and thus may improve endothelial function and retard AS development. Design/Setting/Participants This was a prospective cohort study of 12 healthy regularly menstruating female volunteers. ApoE-/- mice were used as the… CONTINUE READING
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