17&bgr;-Estradiol protects against glucosamine-induced pancreatic &bgr;-cell dysfunction

@article{Kang201417bgrEstradiolPA,
  title={17&bgr;-Estradiol protects against glucosamine-induced pancreatic &bgr;-cell dysfunction},
  author={L. Kang and Chung-Hwan Chen and M. Wu and J. Chang and F. Chang and J. Cheng},
  journal={Menopause},
  year={2014},
  volume={21},
  pages={1239–1248}
}
  • L. Kang, Chung-Hwan Chen, +3 authors J. Cheng
  • Published 2014
  • Medicine
  • Menopause
  • ObjectiveGlucosamine (GlcN) is a popular supplement for osteoarthritis in postmenopausal women. Although GlcN possibly induces insulin resistance, the effects of GlcN on &bgr;-cell dysfunction are still obscure. MethodsIn the present study, we investigated changes in insulin production and &bgr;-cell apoptosis in pancreatic islets after GlcN treatment in rats with or without ovariectomy and used MIN-6 cells to investigate the protective effects and molecular mechanisms of 17&bgr;-estradiol (E2… CONTINUE READING
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