17&bgr;-Estradiol protects against glucosamine-induced pancreatic &bgr;-cell dysfunction

  title={17&bgr;-Estradiol protects against glucosamine-induced pancreatic &bgr;-cell dysfunction},
  author={L. Kang and Chung-Hwan Chen and M. Wu and J. Chang and F. Chang and J. Cheng},
  • L. Kang, Chung-Hwan Chen, +3 authors J. Cheng
  • Published 2014
  • Medicine
  • Menopause
  • ObjectiveGlucosamine (GlcN) is a popular supplement for osteoarthritis in postmenopausal women. Although GlcN possibly induces insulin resistance, the effects of GlcN on &bgr;-cell dysfunction are still obscure. MethodsIn the present study, we investigated changes in insulin production and &bgr;-cell apoptosis in pancreatic islets after GlcN treatment in rats with or without ovariectomy and used MIN-6 cells to investigate the protective effects and molecular mechanisms of 17&bgr;-estradiol (E2… CONTINUE READING
    Exercise training ameliorates glucosamine-induced insulin resistance in ovariectomized rats
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    Another link between exercise and relief from postmenopausal decline.


    Publications referenced by this paper.
    β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
    • 3,109
    • Open Access
    The role for endoplasmic reticulum stress in diabetes mellitus.
    • 928
    • Open Access
    Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes.
    • 800
    • Open Access
    Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice.
    • 349
    • Open Access
    Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells
    • 1,006
    The role of estrogens in control of energy balance and glucose homeostasis.
    • 538
    • Open Access
    Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice.
    • 291
    • Open Access
    The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
    • 321
    • Highly Influential
    • Open Access