16S rRNA gene sequencing reveals site-specific signatures of the upper and lower airways of cystic fibrosis patients.

@article{Lucas201716SRG,
  title={16S rRNA gene sequencing reveals site-specific signatures of the upper and lower airways of cystic fibrosis patients.},
  author={Sarah K. Lucas and Robert Z. Yang and Jordan Dunitz and Holly C. Boyer and Ryan C Hunter},
  journal={Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society},
  year={2017},
  volume={17 2},
  pages={
          204-212
        }
}
BACKGROUND Metastasis of upper airway microbiota may have significant implications in the development of chronic lung disease. Here, we compare bacterial communities of matched sinus and lung mucus samples from cystic fibrosis (CF) subjects undergoing endoscopic surgery for treatment of chronic sinusitis. METHODS Mucus from one maxillary sinus and expectorated sputum were collected from twelve patients. 16S rRNA gene sequencing was then performed on sample pairs to compare the structure and… CONTINUE READING
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