16S rRNA Mutation Associated with Tetracycline Resistance in a Gram-Positive Bacterium

  title={16S rRNA Mutation Associated with Tetracycline Resistance in a Gram-Positive Bacterium},
  author={J. Ross and E. A. Eady and J. Cove and W. Cunliffe},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={1702 - 1705}
  • J. Ross, E. A. Eady, +1 author W. Cunliffe
  • Published 1998
  • Biology, Medicine
  • Antimicrobial Agents and Chemotherapy
  • ABSTRACT A genetic basis for tetracycline resistance in cutaneous propionibacteria was suggested by comparing the nucleotide sequences of the 16S rRNA genes from 16 susceptible and 21 resistant clinical isolates and 6 laboratory-selected tetracycline-resistant mutants of a susceptible strain. Fifteen clinical isolates resistant to tetracycline were found to have cytosine instead of guanine at a position cognate with Escherichia coli 16S rRNA base 1058 in a region important for peptide chain… CONTINUE READING
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