Endorphins, endogenous neurotransmitters with opiate-like properties, are suspected to modify respiratory drive. Naloxone, a specific opiate antagonist, has been shown to enhance respiratory output (RO) in adult cats (Lawson, JAP 47:1105, 1979) and spontaneously breathing rabbits ≤4 days but not in rabbits ≥5 days (Hazinsky, Ped Res 14:643, 1980). To… (More)
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