163. Engineered of a Highly Efficient Cell Cycle Regulatable-HSV-1 Amplicon Viral Vector

@inproceedings{Wang2005163EO,
  title={163. Engineered of a Highly Efficient Cell Cycle Regulatable-HSV-1 Amplicon Viral Vector},
  author={Grace Wang and Ivy A.W. Ho and Kam Man Hui and Paula Y.P. Lam},
  year={2005}
}
We have demonstrated in our previous study that when cell cycle specific-regulatory elements are incorporated in cis into a single HSV-1 amplicon plasmid vector backbone (denoted pC8-36), reporter luciferase activities can be regulated in a cell cycle-dependent manner. This was not observed in the construct (pIH8GalLuc) without the cell cycle regulatory elements, which serve as the negative control. The strategy taken is based on a transcriptional repressor protein termed cell-cycle-dependent… CONTINUE READING