16 alpha-hydroxylation of estradiol: a possible risk marker for breast cancer.

@article{Bradlow198616AO,
  title={16 alpha-hydroxylation of estradiol: a possible risk marker for breast cancer.},
  author={H. Leon Bradlow and R J Hershcopf and Charles Martucci and J F Fishman},
  journal={Annals of the New York Academy of Sciences},
  year={1986},
  volume={464},
  pages={138-51}
}
From these results we may conclude that estradiol 16 alpha-hydroxylation is highly correlated with tumor incidence, and that the reaction is partly regulated by MMTV and the rest by genetic influences. Elevated hydroxylation appears to be an autosomal dominant trait that is highly specific for estradiol. It is also pertinent that the product of the 16 alpha-hydroxyestrone reaction is a potent estrogen that is capable of binding covalently to amino acids and nucleotides, including the estrogen… CONTINUE READING

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