16-P021 Isolation of NOCE, a novel node and notochord-specific enhancer element from the Noto locus


Meckel–Gruber syndrome (MKS) is a rare lethal autosomal recessive disease that is the most common cause of syndromic neural tube defects. There are five causative genes, mapped to six known disease loci, whose products encode proteins involved in formation and function of primary cilia. One of these genes, MKS3 (located on chromosome 8q22.1), is now well… (More)
DOI: 10.1016/j.mod.2009.06.712